New PDF release: Alcoholism: A Molecular Perspective

By Charles S. Lieber (auth.), T. Norman Palmer (eds.)

ISBN-10: 1468459465

ISBN-13: 9781468459463

ISBN-10: 1468459481

ISBN-13: 9781468459487

This ebook comprises chosen court cases from the NATO complicated research Institute (AS I) "The Molecular Pathology of Alcoholism" held on the inn Il Ciocco in Tuscany in the course of twenty sixth August - sixth September 1990. Alcoholism is still probably the most not easy difficulties in remedy, with far-reaching clinical, social and financial effects. for instance within the U. S. , estimates point out that 18 million humans have a significant ingesting challenge and that the full price to the financial system of alcohol abuse is $117 billion. therapy of alcohol dependence and different alcohol-related problems bills for nearly 15% of the full wellbeing and fitness invoice of the U.S.. regardless of the dimensions of the clinical challenge, biomedical study on alcoholism is still anything of a 'Cinderella science'. examine investment from executive and different our bodies is comparatively bad and the variety of clinical scientists operating within the box is still small. The Organizing Committee for this NATO ASI, comprising Charles Lieber (New York), Timothy Peters (London), Mario Dianzani (Torino), Emanuele Albano (Torino) and Norman Palmer (perth, Director), have been accordingly relatively thankful to the NATO medical Affairs department for his or her energetic aid of this AS I, the 1st facing an issue concerning alcohol abuse. We additionally wish that this help will proceed. The subject matter of the ASI was once a detailed dialogue of the molecular occasions initiated by way of alcohol abuse that culminate in onset of alcohol-related disease.

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1977. Reconstitution of the microsomal ethanol-oxidizing system: qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption. J. BioI. , 252, 7124-7131. S. 1977. Hepatic mammalian collagenase: Development of an assay and demonstration of reversal activity after ethanol consumption. Gastroenterology, 73, 1236. S. 1973. Alcohol as a stimulus to hepatic fibrogenesis. J. Alcoholism, 8, 13-27. , and Hess, M. 1983. Immunohistochemical localization of alcohol dehydrogenase in the human gastrointestinal tract.

260, 6385-6393. , and Levin, W. 1986. Evidence that isoniazid and ethanol induced the same microsomal cytochrome P-450 in rat liver, and isozyme homologous to rabbit liver cytochrome P-450 isozymes 3a. Arch. Biochem. , 246 , 633-644. S. 1981. Attenuation of the ethanol induced hepatic redox change after chronic alcohol consumption in baboons: metabolic consequences in vivo and in vitro. Hepatology, 1, 33-38. S. 1981. Mechanism of preventive effect on acetaminopheninduced hepatotoxicity. J. Pharmacol.

1971. Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats. Am. J. , 51, 346-351. H. 1978. The direct oxidation of ethanol by catalase- and alcohol dehydrogenase-free reconstituted system containing cytochrome P-450. Arch. Biochem. , 187, 464-475. 1. 1982. Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. J. BioI. , 257, 13951-13957. 1. 1983. Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen.

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Alcoholism: A Molecular Perspective by Charles S. Lieber (auth.), T. Norman Palmer (eds.)


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